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Oligonucleotide properties calculator

Length, base composition, molecular weight, extinction coefficient, OD conversions, three melting-temperature methods and self-complementarity checks. Everything is calculated in your browser — the sequence is never uploaded.

Sequence

0 bases. Degenerate IUPAC codes are accepted.

Properties

Length
0 nt
GC content
0.0 %
Composition
A0 C0 G0 T0
MW single strand
0.0 g/mol
MW double strand
0.0 g/mol
Extinction coeff.
0 M⁻¹cm⁻¹
µg per OD₂₆₀
0.0
nmol per OD₂₆₀
0.00
Hairpin score
0
Self-dimer score
0

Hairpin and self-dimer scores are complementarity counts — higher means more structure. Anything above about 8 is worth redesigning.

Melting temperature

Basic (Wallace / GC)
0.0 °C
Salt adjusted
0.0 °C
Nearest neighbour
0.0 °C

Use the nearest-neighbour value for qPCR design; it accounts for salt, Mg²⁺, dNTPs and oligo concentration.

Sequence transforms

Reverse
Complement
Reverse complement